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Peripheral cryobiopsy

Peripheral pulmonary lesions

  • With the flexible 1.1mm cryoprobe you can achieve an accurate biopsy of peripheral lung lesions. This reduces deflection of the rEBUS guide sheath when inserting the cryoprobe.

  • Quantify the expression of PD-L1 (programmed cell death ligand 1) in bronchial neoplasm with suitable material from cryobiopsy.

  • Next-generation sequencing is also possible from cryobiopsy material in a higher quality compared to EBUS-guided transbronchial needle aspiration.

  • You can also use cryobiopsies for immunohistochemical evaluation of bronchial neoplasia.

  • Achieve deeper sampling in peripheral lung lesions with cryobiopsy compared to standard forceps. This is beneficial when sampling lesions with incomplete mucosal invasion in a difficult or adjacent location.

Application videos

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Sampling of peripheral lung nodules with cryo – ERS Congress 2021

Scientific information

Medical insights ePaper

Peripheral cryobiopsy for solitary pulmonary nodules. 1.1mm flexible single-use cryoprobe for the diagnosis of sub-solid lesions.
 

Ground-glass opacity lesions (GGOs) respresent a subgroup of sub-solid lesions, which are characterized by an increased opacity of lung tissue on high- resolution computed tomography. Different techniques have been described in the literature for biopsy of peripheral lesions (transthoracic needle aspiration, transbronchial forceps biopsy or cryobiopsy and surgical lung biopsy). Using interventional pulmonological procedures, GGOs can be harder to diagnose compared to solid lesions. Jiang et al. conducted the first study evaluating the clinical use of the 1.1mm flexible single-use cryoprobe on peripheral cryobiopsy specifically for the diagnosis of GGOs.
 

Check out the e-Paper

Medical insights ePaper

Cryobiopsy vs forceps for bronchoscopic lung biopsy: The FROSTBITE-2 randomized clinical trial
 

The FROSTBITE-2 trial demonstrated that transbronchial biopsy with an Erbe 1.1-mm cryoprobe achieved significantly higher overall diagnostic yield compared with forceps biopsy, without an increase in major procedural complications. No grade ≥3 bleeding events, respiratory failure events, or deaths were observed in the cryoprobe group.


Check out the e-Paper

Products for this intervention

No. 20402-410

No. 20402-410

Flexible cryoprobe single-use, ø 1.7mm, length 1150mm

No. 20402-401

No. 20402-401

Flexible cryoprobe single-use, ø 1.1mm, length 1150mm, with oversheath, length 817mm, with oversheath ø 2.6mm

No. 20402-402

No. 20402-402

Flexible cryoprobe single-use, ø 1.1mm, length 1150mm with oversheath, length 757mm, with oversheath ø 2.6mm No. 20402-402

More PRODUCT Info

 

  • Miniaturization extends your clinical utility due to compatibility with navigation catheters and small bronchoscopes (1.7mm and 1.2mm working channels).

  • Reliable technical performance supports consistent target tissue effects.